MolNFT v1 · #53717 · protein
Crystal structure of the R139N mutant of a bifunctional enzyme pria
2X30 · Phosphoribosyl isomerase a: “Crystal structure of the R139N mutant of a bifunctional enzyme pria”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.79). MolNFT v1 #53717 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2X30
- Type
- protein
- Length
- 233 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosyl isomerase a
- EC
- 5.3.1.16, 5.3.1.24
- UniProt
- P16250
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosyl isomerase a (EC 5.3.1.16, 5.3.1.24) | protein | 233 | 41% helix, 25% strand | P16250 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.79 | 0.86 | 56 | SO4 |
| 2 | 58 | 0.59 | 0.91 | 15 | empty |
Compared structures
- 2X30 · Crystal structure of the r139n mutant of a bifunctional enzyme pria · the same entry in another collection · chain A against A, TM-score 1.00
- P16250 · AlphaFold monomer V2.0 prediction for phosphoribosyl isomerase a (P16250) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16250
- Elsewhere: RCSB PDB 2X30 · PDBe 2X30 · UniProt P16250
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