MolNFT v1 · #53672 · protein
Gelsolin nanobody
2X1P: “Gelsolin nanobody”. X-ray diffraction, 8 pockets (best druggability 0.55). MolNFT v1 #53672 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2X1P
- Type
- protein
- Length
- 472 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gelsolin nanobody
- Pockets
- 8 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Gelsolin nanobody | protein | 118 | 5% helix, 47% strand | — |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 291 | 0.55 | 0.76 | 50 | empty |
| 2 | 65 | 0.46 | 0.83 | 17 | empty |
| 3 | 65 | 0.45 | 0.83 | 17 | empty |
| 4 | 72 | 0.44 | 0.81 | 17 | empty |
| 5 | 71 | 0.42 | 0.80 | 17 | empty |
Interfaces
5 interfaces between chains.
- C–D · 457 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 454 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 440 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 196 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 112 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2X1P · Gelsolin Nanobody · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2X1P · PDBe 2X1P
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