MolNFT v1 · #53606 · protein

The structure of foot and mouth disease virus serotype SAT1

2WZR · Polyprotein: “The structure of foot and mouth disease virus serotype SAT1”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #53606 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2WZR
Type: protein
Length: 666 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyprotein
UniProt: Q6PMU1
Pockets: 7 · best druggability 0.73

Structure

x-ray diffraction · 4 distinct chains · 11% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
1	Polyprotein	protein	192	12% helix, 29% strand	Q6PMU1
2	Polyprotein	protein	207	11% helix, 46% strand	Q6PMU1
3	Polyprotein	protein	221	8% helix, 31% strand	Q6PMU1
4	Polyprotein	protein	46	24% helix, 2% strand	Q6PMU1

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	632	0.73	0.80	64	empty
2	546	0.70	0.79	44	empty
3	380	0.66	0.80	37	empty
4	75	0.61	0.90	21	empty
5	183	0.52	0.78	22	empty

Interfaces

6 interfaces between chains.

1–2 · 1525 Å² buried · 19 hydrogen bonds · protein-protein
1–3 · 1204 Å² buried · 19 hydrogen bonds · protein-protein
2–3 · 866 Å² buried · 9 hydrogen bonds · protein-protein
1–4 · 763 Å² buried · 14 hydrogen bonds · protein-protein
2–4 · 240 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2WZR · The Structure of Foot and Mouth Disease Virus Serotype SAT1 · the same entry in another collection · chain 1 against 1, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6PMU1
Elsewhere: RCSB PDB 2WZR · PDBe 2WZR · UniProt Q6PMU1

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