MolNFT v1 · #53549 · protein

Crystal structure of rat angiotensinogen in P321 space group

2WY1: “Crystal structure of rat angiotensinogen in P321 space group”. X-ray diffraction, 7 pockets (best druggability 0.70). MolNFT v1 #53549 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2WY1
Type: protein
Length: 835 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiotensinogen
UniProt: P01015
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Angiotensinogen	protein	418	30% helix, 27% strand	P01015
B	Angiotensinogen	protein	417	31% helix, 29% strand	P01015

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	606	0.70	0.79	74	empty
2	597	0.70	0.78	78	empty
3	107	0.40	0.76	20	empty
4	105	0.38	0.75	19	empty
5	77	0.30	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 453 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2WY1 · Crystal structure of rat angiotensinogen in P321 space group · the same entry in another collection · chain A against A, TM-score 1.00
P01015 · AlphaFold monomer V2.0 prediction for angiotensinogen (P01015) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01015
Elsewhere: RCSB PDB 2WY1 · PDBe 2WY1 · UniProt P01015

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