MolNFT v1 · #53515 · protein
Crystal structure of the SIDM/DRRA(GEF/GDF domain)-RAB1 (GTPase domain) complex
2WWX · RAS-related protein rab-1: “Crystal structure of the SIDM/DRRA(GEF/GDF domain)-RAB1 (GTPase domain) complex”. X-ray diffraction, 3 pockets (best druggability 0.51). MolNFT v1 #53515 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2WWX
- Type
- protein
- Length
- 369 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAS-related protein rab-1; Drra
- UniProt
- P62820, Q29ST3
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAS-related protein rab-1 | protein | 169 | 37% helix, 27% strand | P62820 |
| B | Drra | protein | 200 | 66% helix, 2% strand | Q29ST3 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.51 | 0.76 | 43 | empty |
| 2 | 151 | 0.44 | 0.76 | 21 | empty |
| 3 | 107 | 0.36 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1775 Ų buried · 31 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2WWX · Crystal structure of the SidM/DrrA(GEF/GDF domain)-Rab1(GTPase domain) complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q29ST3 · AlphaFold monomer V2.0 prediction for multifunctional virulence effector protein drra… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P62820 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-1A (P62820) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62820
- Every structure of UniProt Q29ST3
- Elsewhere: RCSB PDB 2WWX · PDBe 2WWX · UniProt P62820 · UniProt Q29ST3
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