MolNFT v1 · #53457 · protein

Crystal structure of the NS3 protease-helicase from murray valley encephalitis virus

2WV9 · Flavivirin protease NS2B regulatory subunit, flavivirin…: “Crystal structure of the NS3 protease-helicase from murray valley encephalitis virus”. X-ray diffraction, 5 pockets (best druggability 0.76). MolNFT v1 #53457 on GenesisL1…

PDB: 2WV9
Type: protein
Length: 601 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Flavivirin protease NS2B regulatory subunit, flavivirin protease NS3 catalytic subunit
EC: 3.4.21.91
UniProt: P05769
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Flavivirin protease NS2B regulatory subunit, flavivirin protease NS3 catalytic subunit (EC 3.4.21.91)	protein	601	26% helix, 25% strand	P05769

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1144	0.76	0.78	78	empty
2	348	0.71	0.84	49	empty
3	51	0.52	0.88	13	empty
4	185	0.45	0.74	27	empty
5	78	0.35	0.76	19	empty

Compared structures

2WV9 · Crystal Structure of the NS3 protease-helicase from Murray Valley encephalitis virus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05769
Elsewhere: RCSB PDB 2WV9 · PDBe 2WV9 · UniProt P05769

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