MolNFT v1 · #53438 · protein
Crystal structure of blab protein from streptomyces cacaoi
2WUQ · Beta-lactamase regulatory protein blab: “Crystal structure of blab protein from streptomyces cacaoi”. X-ray diffraction, 2 pockets (best druggability 0.81). MolNFT v1 #53438 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2WUQ
- Type
- protein
- Length
- 560 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-lactamase regulatory protein blab
- UniProt
- P33652
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-lactamase regulatory protein blab | protein | 277 | 44% helix, 20% strand | P33652 |
| B | Beta-lactamase regulatory protein blab | protein | 283 | 42% helix, 20% strand | P33652 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1191 | 0.81 | 0.82 | 125 | empty |
| 2 | 68 | 0.52 | 0.86 | 17 | GOL |
Interfaces
1 interface between chains.
- A–B · 1426 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 2WUQ · Crystal structure of BlaB protein from Streptomyces cacaoi · the same entry in another collection · chain A against A, TM-score 1.00
- P33652 · AlphaFold monomer V2.0 prediction for beta-lactamase regulatory protein blab (P33652) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33652
- Elsewhere: RCSB PDB 2WUQ · PDBe 2WUQ · UniProt P33652
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