MolNFT v1 · #53424 · protein

Structural studies of phosphoglucose isomerase from mycobacterium tuberculosis H37RV

2WU8 · Glucose-6-phosphate isomerase: “Structural studies of phosphoglucose isomerase from mycobacterium tuberculosis H37RV”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.60). MolNFT v1 #53424 on GenesisL1: 3D…

PDB: 2WU8
Type: protein
Length: 549 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucose-6-phosphate isomerase
EC: 5.3.1.9
UniProt: P64192
Ligands: SO4
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucose-6-phosphate isomerase (EC 5.3.1.9)	protein	549	54% helix, 13% strand	P64192

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	347	0.60	0.77	39	SO4
2	194	0.54	0.79	22	empty
3	147	0.50	0.79	26	empty
4	79	0.37	0.77	16	empty
5	56	0.32	0.76	12	empty

Compared structures

2WU8 · Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P64192
Elsewhere: RCSB PDB 2WU8 · PDBe 2WU8 · UniProt P64192

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