MolNFT v1 · #53170 · protein
Crystal structure of a mammalian sialyltransferase
2WML · Cmp-N-acetylneuraminate-beta-galactosamide…: “Crystal structure of a mammalian sialyltransferase”. X-ray diffraction, 1 ligand (CL), 4 pockets (best druggability 0.59). MolNFT v1 #53170 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2WML
- Type
- protein
- Length
- 276 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cmp-N-acetylneuraminate-beta-galactosamide -alpha-2\,3-sialyltransferase
- EC
- 2.4.99.4
- UniProt
- Q02745
- Ligands
- CL
- Pockets
- 4 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cmp-N-acetylneuraminate-beta-galactosamide -alpha-2\,3-sialyltransferase (EC 2.4.99.4) | protein | 276 | 32% helix, 13% strand | Q02745 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 344 | 0.59 | 0.77 | 43 | GOL |
| 2 | 53 | 0.39 | 0.81 | 15 | empty |
| 3 | 58 | 0.29 | 0.74 | 13 | empty |
| 4 | 50 | 0.26 | 0.74 | 14 | empty |
Modifications
Observed in the structure: 3 disulfide, 3 modified (disulfide, engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02745
- Elsewhere: RCSB PDB 2WML · PDBe 2WML · UniProt Q02745
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