MolNFT v1 · #53138 · protein

Potassium channel from magnetospirillum magnetotacticum

2WLN: “Potassium channel from magnetospirillum magnetotacticum”. X-ray diffraction, 1 ligand (K), 20 pockets (best druggability 0.83). MolNFT v1 #53138 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2WLN
Type: protein
Length: 2,264 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Potassium channel
Ligands: K
Pockets: 20 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Potassium channel	protein	283	31% helix, 33% strand	—

Ligands and binding sites

K · Potassium ion · metal · 6 copies · chains A, B, C, D, E, F, G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1101	0.83	0.84	95	empty
2	980	0.83	0.84	99	empty
3	960	0.83	0.84	96	empty
4	675	0.80	0.84	72	empty
5	532	0.75	0.83	43	empty

Interfaces

15 interfaces between chains.

E–F · 2369 Å² buried · 28 hydrogen bonds · protein-protein
G–H · 2336 Å² buried · 26 hydrogen bonds · protein-protein
B–C · 2313 Å² buried · 24 hydrogen bonds · protein-protein
A–D · 2300 Å² buried · 25 hydrogen bonds · protein-protein
C–D · 2285 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

2WLN · Potassium channel from magnetospirillum magnetotacticum · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2WLN · PDBe 2WLN

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