MolNFT v1 · #52968 · protein

Crystal structure of helicobactor pylori uref

2WGL · Urease accessory protein uref: “Crystal structure of helicobactor pylori uref”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #52968 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2WGL
Type: protein
Length: 627 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urease accessory protein uref
UniProt: Q09065
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Urease accessory protein uref	protein	209	72% helix, 0% strand	Q09065

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	282	0.71	0.85	38	empty
2	262	0.70	0.85	37	empty
3	160	0.65	0.86	26	empty
4	197	0.64	0.84	32	empty

Interfaces

2 interfaces between chains.

A–C · 1752 Å² buried · 18 hydrogen bonds · protein-protein
A–B · 288 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

2WGL · Crystal structure of Helicobactor pylori UreF · the same entry in another collection · chain A against A, TM-score 1.00
Q09065 · AlphaFold monomer V2.0 prediction for urease accessory protein uref (Q09065) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q09065
Elsewhere: RCSB PDB 2WGL · PDBe 2WGL · UniProt Q09065

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