MolNFT v1 · #52959 · protein
Crystal structure of the tetr-like transcriptional regulator lfrr from mycobacterium smegmatis
2WGB · Tetr family transcriptional repressor lfrr: “Crystal structure of the tetr-like transcriptional regulator lfrr from mycobacterium smegmatis”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.48). MolNFT v1 #52959 on…
- PDB
- 2WGB
- Type
- protein
- Length
- 325 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetr family transcriptional repressor lfrr
- UniProt
- Q58L87
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetr family transcriptional repressor lfrr | protein | 175 | 71% helix, 0% strand | Q58L87 |
| B | Tetr family transcriptional repressor lfrr | protein | 150 | 75% helix, 0% strand | Q58L87 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.48 | 0.82 | 20 | empty |
| 2 | 71 | 0.38 | 0.78 | 17 | empty |
| 3 | 59 | 0.33 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1968 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 2WGB · Crystal structure of the TetR-like transcriptional regulator LfrR from Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58L87
- Elsewhere: RCSB PDB 2WGB · PDBe 2WGB · UniProt Q58L87
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