MolNFT v1 · #52920 · protein
Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphonate and aluminium tetrafluoride
2WF7: “Structure of beta-phosphoglucomutase inhibited with glucose-6- phosphonate and aluminium tetrafluoride”. X-ray diffraction, 3 ligands (ALF, G7P, MG), 2 pockets (best druggability 0.74). MolNFT v1 #52920 on GenesisL1: 3D structure…
- PDB
- 2WF7
- Type
- protein
- Length
- 218 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-phosphoglucomutase
- EC
- 5.4.2.6
- UniProt
- P71447
- Ligands
- ALF, G7P, MG
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-phosphoglucomutase (EC 5.4.2.6) | protein | 218 | 51% helix, 12% strand | P71447 |
Ligands and binding sites
- ALF · Tetrafluoroaluminate ion · ligand · chains A
- G7P · 6,7-dideoxy-7-phosphono-beta-D-gluco-heptopyranose · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 150 | 0.74 | 0.92 | 33 | ALF, MG, G7P |
| 2 | 119 | 0.42 | 0.76 | 19 | empty |
Compared structures
- 2WF7 · Structure of Beta-Phosphoglucomutase inhibited with Glucose-6- phosphonate and Aluminium… · the same entry in another collection · chain A against A, TM-score 1.00
- P71447 · AlphaFold monomer V2.0 prediction for beta-phosphoglucomutase (P71447) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71447
- Elsewhere: RCSB PDB 2WF7 · PDBe 2WF7 · UniProt P71447
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