MolNFT v1 · #52749 · protein

Structure of the methyltransferase domain from modoc virus, a flavivirus with no known vector (nkv)

2WA2 · Non-structural protein 5: “Structure of the methyltransferase domain from modoc virus, a flavivirus with no known vector (nkv)”. X-ray diffraction, 2 ligands (SAM, SO4), 1 pocket (best druggability 0.81). MolNFT v1 #52749 on…

PDB: 2WA2
Type: protein
Length: 482 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 5
UniProt: Q8QL64
Ligands: SAM, SO4
Pockets: 1 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Non-structural protein 5	protein	223	44% helix, 15% strand	Q8QL64
B	Non-structural protein 5	protein	259	38% helix, 18% strand	Q8QL64

Ligands and binding sites

SAM · S-adenosylmethionine · ligand · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	868	0.81	0.83	106	SAM

Interfaces

1 interface between chains.

A–B · 498 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

2WA2 · Structure of the methyltransferase domain from Modoc Virus, a Flavivirus with No Known… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8QL64
Elsewhere: RCSB PDB 2WA2 · PDBe 2WA2 · UniProt Q8QL64

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