MolNFT v1 · #52701 · protein
The crystal structure of the reduced form of human ssadh
2W8O · Succinic semialdehyde dehydrogenase mitochondrial: “The crystal structure of the reduced form of human ssadh”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.66). MolNFT v1 #52701 on GenesisL1: 3D structure…
- PDB
- 2W8O
- Type
- protein
- Length
- 480 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Succinic semialdehyde dehydrogenase mitochondrial
- EC
- 1.2.1.24
- UniProt
- P51649
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Succinic semialdehyde dehydrogenase mitochondrial (EC 1.2.1.24) | protein | 480 | 40% helix, 20% strand | P51649 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.66 | 0.94 | 20 | SO4 |
| 2 | 372 | 0.59 | 0.76 | 44 | SO4 |
| 3 | 130 | 0.48 | 0.78 | 19 | empty |
| 4 | 139 | 0.42 | 0.75 | 26 | SO4 |
| 5 | 92 | 0.36 | 0.75 | 19 | GOL |
Compared structures
- 2W8O · The crystal structure of the reduced form of human SSADH · the same entry in another collection · chain A against A, TM-score 1.00
- P51649 · AlphaFold monomer V2.0 prediction for succinate-semialdehyde dehydrogenase, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51649
- Elsewhere: RCSB PDB 2W8O · PDBe 2W8O · UniProt P51649
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