MolNFT v1 · #52700 · protein
The crystal structure of the oxidized form of human ssadh
2W8N · Succinate-semialdehyde dehydrogenase, mitochondrial: “The crystal structure of the oxidized form of human ssadh”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.82). MolNFT v1 #52700 on GenesisL1: 3D structure…
- PDB
- 2W8N
- Type
- protein
- Length
- 480 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Succinate-semialdehyde dehydrogenase, mitochondrial
- EC
- 1.2.1.24
- UniProt
- P51649
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) | protein | 480 | 41% helix, 23% strand | P51649 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 8 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 687 | 0.82 | 0.86 | 59 | empty |
| 2 | 87 | 0.57 | 0.86 | 18 | empty |
| 3 | 68 | 0.32 | 0.75 | 16 | SO4 |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2W8N · The crystal structure of the oxidized form of human SSADH · the same entry in another collection · chain A against A, TM-score 1.00
- P51649 · AlphaFold monomer V2.0 prediction for succinate-semialdehyde dehydrogenase, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51649
- Elsewhere: RCSB PDB 2W8N · PDBe 2W8N · UniProt P51649
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