MolNFT v1 · #52565 · protein
The crystal structure of human N-acetylneuraminic acid phosphatase, nanp
2W4M · N-acylneuraminate-9-phosphatase: “The crystal structure of human N-acetylneuraminic acid phosphatase, nanp”. X-ray diffraction, 3 ligands (NA, CL, PO4), 2 pockets (best druggability 0.47). MolNFT v1 #52565 on GenesisL1: 3D…
- PDB
- 2W4M
- Type
- protein
- Length
- 250 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- N-acylneuraminate-9-phosphatase
- EC
- 3.1.3.29
- UniProt
- Q8TBE9
- Ligands
- NA, CL, PO4
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | N-acylneuraminate-9-phosphatase (EC 3.1.3.29) | protein | 250 | 55% helix, 12% strand | Q8TBE9 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A
- CL · Chloride ion · ion · 2 copies · chains A
- PO4 · Phosphate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 244 | 0.47 | 0.74 | 30 | NA, CL, PO4 |
| 2 | 99 | 0.36 | 0.74 | 21 | empty |
Compared structures
- 2W4M · The Crystal Structure of human N-acetylneuraminic acid phosphatase, NANP · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TBE9 · AlphaFold monomer V2.0 prediction for N-acylneuraminate-9-phosphatase (Q8TBE9) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TBE9
- Elsewhere: RCSB PDB 2W4M · PDBe 2W4M · UniProt Q8TBE9
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