MolNFT v1 · #52553 · protein
Isometrically contracting insect asynchronous flight muscle
2W4A · Myosin regulatory light chain 2, skeletal muscle isoform: “Isometrically contracting insect asynchronous flight muscle”. Electron microscopy, 18 pockets (best druggability 0.75). MolNFT v1 #52553 on GenesisL1: 3D structure, binding…
- PDB
- 2W4A
- Type
- protein
- Length
- 1,099 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin regulatory light chain 2, skeletal muscle isoform; Myosin light chain 3, skeletal…
- UniProt
- P02609, P02605, P13538
- Pockets
- 18 · best druggability 0.75
Structure
electron microscopy · 3 distinct chains · 50% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Myosin regulatory light chain 2, skeletal muscle isoform | protein | 150 | 56% helix, 0% strand | P02609 |
| C | Myosin light chain 3, skeletal muscle isoform | protein | 145 | 57% helix, 4% strand | P02605 |
| M | Myosin heavy chain, skeletal muscle, adult | protein | 804 | 47% helix, 14% strand | P13538 |
Pockets
18 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 283 | 0.75 | 0.87 | 53 | empty |
| 2 | 340 | 0.72 | 0.84 | 49 | empty |
| 3 | 57 | 0.72 | 0.98 | 22 | empty |
| 4 | 134 | 0.69 | 0.90 | 24 | empty |
| 5 | 63 | 0.66 | 0.93 | 19 | empty |
Interfaces
3 interfaces between chains.
- B–M · 1955 Ų buried · 22 hydrogen bonds · protein-protein
- C–M · 1690 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 237 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 isopeptide (isopeptide).
Compared structures
- 2W4A · Isometrically contracting insect asynchronous flight muscle · the same entry in another collection · chain C against C, TM-score 1.00
- P02605 · AlphaFold monomer V2.0 prediction for myosin light chain 3, skeletal muscle isoform… · a predicted model of the same protein · chain C against A, TM-score 0.87
- P02609 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain 2, skeletal muscle… · a predicted model of the same protein · chain B against A, TM-score 0.81
- P13538 · AlphaFold monomer V2.0 prediction for myosin heavy chain, skeletal muscle, adult (P13538) · a predicted model of the same protein · chain M against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02609
- Every structure of UniProt P02605
- Every structure of UniProt P13538
- Elsewhere: RCSB PDB 2W4A · PDBe 2W4A · UniProt P02609 · UniProt P02605 · UniProt P13538
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