MolNFT v1 · #52519 · protein
Globular head region of the human general vesicular transport factor P115
2W3C: “Globular head region of the human general vesicular transport factor P115”. X-ray diffraction, 5 pockets (best druggability 0.57). MolNFT v1 #52519 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2W3C
- Type
- protein
- Length
- 551 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- General vesicular transport factor P115
- UniProt
- O60763
- Pockets
- 5 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 68% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | General vesicular transport factor P115 | protein | 551 | 68% helix, 1% strand | O60763 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 142 | 0.57 | 0.82 | 22 | PEG |
| 2 | 63 | 0.52 | 0.86 | 18 | empty |
| 3 | 51 | 0.38 | 0.81 | 11 | empty |
| 4 | 114 | 0.36 | 0.74 | 23 | empty |
| 5 | 55 | 0.28 | 0.74 | 14 | empty |
Compared structures
- 2W3C · Globular head region of the human general vesicular transport factor p115 · the same entry in another collection · chain A against A, TM-score 1.00
- O60763 · AlphaFold monomer V2.0 prediction for general vesicular transport factor P115 (O60763) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60763
- Elsewhere: RCSB PDB 2W3C · PDBe 2W3C · UniProt O60763
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