MolNFT v1 · #52328 · protein

Crystal structure of the conserved C-terminal region of ge- 1

2VXG · CG6181-pa, isoform a: “Crystal structure of the conserved C-terminal region of ge- 1”. X-ray diffraction, 2 pockets (best druggability 0.41). MolNFT v1 #52328 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2VXG
Type: protein
Length: 259 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CG6181-pa, isoform a
UniProt: Q9VKK1
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CG6181-pa, isoform a	protein	131	76% helix, 0% strand	Q9VKK1
B	CG6181-pa, isoform a	protein	128	77% helix, 0% strand	Q9VKK1

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	85	0.41	0.79	20	empty
2	56	0.30	0.75	18	empty

Interfaces

1 interface between chains.

A–B · 966 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

2VXG · Crystal structure of the conserved C-terminal region of Ge-1 · the same entry in another collection · chain B against B, TM-score 1.00
Q9VKK1 · AlphaFold monomer V2.0 prediction for enhancer of mRNA-decapping protein 4 homolog… · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VKK1
Elsewhere: RCSB PDB 2VXG · PDBe 2VXG · UniProt Q9VKK1

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