MolNFT v1 · #52167 · protein
The structure of the rhodanese domain of the human dual specificity phosphatase 16
2VSW · Dual specificity protein phosphatase 16: “The structure of the rhodanese domain of the human dual specificity phosphatase 16”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #52167 on GenesisL1: 3D structure…
- PDB
- 2VSW
- Type
- protein
- Length
- 268 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dual specificity protein phosphatase 16
- UniProt
- Q9BY84
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Dual specificity protein phosphatase 16 | protein | 134 | 41% helix, 17% strand | Q9BY84 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.43 | 0.79 | 20 | empty |
| 2 | 94 | 0.40 | 0.76 | 25 | empty |
| 3 | 74 | 0.33 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 558 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2VSW · The structure of the rhodanese domain of the human dual specificity phosphatase 16 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BY84 · AlphaFold monomer V2.0 prediction for dual specificity protein phosphatase 16 (Q9BY84) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BY84
- Elsewhere: RCSB PDB 2VSW · PDBe 2VSW · UniProt Q9BY84
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