MolNFT v1 · #51976 · protein

Structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1)

2VNA · Prostaglandin reductase 2: “Structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1)”. X-ray diffraction, 1 ligand (NAP), 1 pocket (best druggability 0.83). MolNFT v1 #51976 on GenesisL1: 3D structure, binding sites and…

PDB: 2VNA
Type: protein
Length: 349 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prostaglandin reductase 2
EC: 1.3.1.48
UniProt: Q8N8N7
Ligands: NAP
Pockets: 1 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prostaglandin reductase 2 (EC 1.3.1.48)	protein	349	33% helix, 28% strand	Q8N8N7

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1064	0.83	0.84	91	NAP

Compared structures

2VNA · Structure of Human Zinc-binding Alcohol Dehydrogenase 1 (ZADH1) · the same entry in another collection · chain A against A, TM-score 1.00
Q8N8N7 · AlphaFold monomer V2.0 prediction for prostaglandin reductase 2 (Q8N8N7) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8N8N7
Elsewhere: RCSB PDB 2VNA · PDBe 2VNA · UniProt Q8N8N7

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