MolNFT v1 · #51926 · protein

Crystal structure of barley thioredoxin H isoform 2 in partially radiation-reduced state

2VLU · Thioredoxin H isoform 2.: “Crystal structure of barley thioredoxin H isoform 2 in partially radiation-reduced state”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #51926 on GenesisL1: 3D structure, binding sites…

PDB: 2VLU
Type: protein
Length: 223 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thioredoxin H isoform 2.
EC: 1.8.1.9
UniProt: Q7XZK2
Pockets: 2 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Thioredoxin H isoform 2. (EC 1.8.1.9)	protein	111	42% helix, 25% strand	Q7XZK2
B	Thioredoxin H isoform 2. (EC 1.8.1.9)	protein	112	42% helix, 25% strand	Q7XZK2

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	158	0.45	0.76	30	empty
2	161	0.44	0.75	23	empty

Interfaces

1 interface between chains.

A–B · 309 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2VLU · Crystal structure of barley thioredoxin h isoform 2 in partially radiation-reduced state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7XZK2
Elsewhere: RCSB PDB 2VLU · PDBe 2VLU · UniProt Q7XZK2

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