MolNFT v1 · #5189 · protein
Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex
1EAA · Dihydrolipoyl-transacetylase: “Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #5189 on GenesisL1: 3D structure, binding sites…
- PDB
- 1EAA
- Type
- protein
- Length
- 243 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydrolipoyl-transacetylase
- EC
- 2.3.1.12
- UniProt
- P10802
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydrolipoyl-transacetylase (EC 2.3.1.12) | protein | 243 | 40% helix, 22% strand | P10802 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.52 | 0.76 | 32 | empty |
| 2 | 215 | 0.51 | 0.76 | 26 | empty |
Compared structures
- 1EAA · Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex · the same entry in another collection · chain A against A, TM-score 1.00
- P10802 · AlphaFold monomer V2.0 prediction for dihydrolipoyllysine-residue acetyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10802
- Elsewhere: RCSB PDB 1EAA · PDBe 1EAA · UniProt P10802
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