MolNFT v1 · #51833 · protein

Methylated shigella flexneri mxic

2VJ4 · Protein mxic: “Methylated shigella flexneri mxic”. X-ray diffraction, 4 pockets (best druggability 0.48). MolNFT v1 #51833 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2VJ4
Type: protein
Length: 584 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein mxic
UniProt: Q04640
Pockets: 4 · best druggability 0.48

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein mxic	protein	292	70% helix, 0% strand	Q04640

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	149	0.48	0.78	18	empty
2	141	0.46	0.77	18	empty
3	221	0.45	0.73	30	empty
4	192	0.45	0.73	28	empty

Interfaces

1 interface between chains.

A–B · 577 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 40 modified (methylation).

Compared structures

2VJ4 · Methylated Shigella flexneri MxiC · the same entry in another collection · chain A against A, TM-score 1.00
Q04640 · AlphaFold monomer V2.0 prediction for protein mxic (Q04640) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04640
Elsewhere: RCSB PDB 2VJ4 · PDBe 2VJ4 · UniProt Q04640

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