MolNFT v1 · #51493 · protein

Structure of corticosteroid-binding globulin in complex with cortisol

2V95: “Structure of corticosteroid-binding globulin in complex with cortisol”. X-ray diffraction, 1 ligand (HCY), 2 pockets (best druggability 0.52). MolNFT v1 #51493 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2V95
Type: protein
Length: 342 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Corticosteroid-binding globulin
UniProt: P31211
Ligands: HCY
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Corticosteroid-binding globulin	protein	342	32% helix, 35% strand	P31211

Ligands and binding sites

HCY · (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.52	0.79	18	HCY
2	102	0.38	0.75	18	empty

Compared structures

2V95 · Structure of Corticosteroid-Binding Globulin in complex with Cortisol · the same entry in another collection · chain A against A, TM-score 1.00
P31211 · AlphaFold monomer V2.0 prediction for corticosteroid-binding globulin (P31211) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31211
Elsewhere: RCSB PDB 2V95 · PDBe 2V95 · UniProt P31211

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