MolNFT v1 · #51329 · protein
Crystal structure of rseb: a sensor for periplasmic stress response in E. COLI
2V43 · Sigma-E factor regulatory protein rseb: “Crystal structure of rseb: a sensor for periplasmic stress response in E. COLI”. X-ray diffraction, 1 ligand (CYS), 3 pockets (best druggability 0.75). MolNFT v1 #51329 on GenesisL1: 3D…
- PDB
- 2V43
- Type
- protein
- Length
- 813 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sigma-E factor regulatory protein rseb
- UniProt
- P0AFX9
- Ligands
- CYS
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 14% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sigma-E factor regulatory protein rseb | protein | 261 | 15% helix, 49% strand | P0AFX9 |
| B | Sigma-E factor regulatory protein rseb | protein | 276 | 14% helix, 50% strand | P0AFX9 |
| C | Sigma-E factor regulatory protein rseb | protein | 276 | 13% helix, 51% strand | P0AFX9 |
Ligands and binding sites
- CYS · Cysteine · ligand · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1182 | 0.75 | 0.78 | 109 | CYS |
| 2 | 256 | 0.57 | 0.78 | 43 | empty |
| 3 | 201 | 0.55 | 0.79 | 39 | empty |
Interfaces
2 interfaces between chains.
- A–B · 896 Ų buried · 29 hydrogen bonds · protein-protein
- A–C · 528 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 2V43 · Crystal structure of RseB: a sensor for periplasmic stress response in E. coli · the same entry in another collection · chain B against B, TM-score 1.00
- P0AFX9 · AlphaFold monomer V2.0 prediction for sigma-E factor regulatory protein rseb (P0AFX9) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AFX9
- Elsewhere: RCSB PDB 2V43 · PDBe 2V43 · UniProt P0AFX9
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