MolNFT v1 · #51286 · protein

Structure of mouse gammac-crystallin

2V2U · Gamma crystallin C: “Structure of mouse gammac-crystallin”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #51286 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2V2U
Type: protein
Length: 346 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gamma crystallin C
UniProt: Q61597
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Gamma crystallin C	protein	173	8% helix, 50% strand	Q61597

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	701	0.72	0.78	66	empty
2	67	0.33	0.76	14	empty
3	60	0.30	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 562 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2V2U · Structure of Mouse gammaC-crystallin · the same entry in another collection · chain A against A, TM-score 1.00
Q61597 · AlphaFold monomer V2.0 prediction for gamma-crystallin C (Q61597) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q61597
Elsewhere: RCSB PDB 2V2U · PDBe 2V2U · UniProt Q61597

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