MolNFT v1 · #51264 · protein
Apo structure of the cold active phenylalanine hydroxylase from colwellia psychrerythraea 34H
2V28 · Phenylalanine-4-hydroxylase: “Apo structure of the cold active phenylalanine hydroxylase from colwellia psychrerythraea 34H”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.75). MolNFT v1 #51264 on GenesisL1: 3D…
- PDB
- 2V28
- Type
- protein
- Length
- 525 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylalanine-4-hydroxylase
- EC
- 1.14.16.1
- UniProt
- Q47XN7
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phenylalanine-4-hydroxylase (EC 1.14.16.1) | protein | 264 | 51% helix, 11% strand | Q47XN7 |
| B | Phenylalanine-4-hydroxylase (EC 1.14.16.1) | protein | 261 | 52% helix, 11% strand | Q47XN7 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 536 | 0.75 | 0.82 | 43 | empty |
| 2 | 518 | 0.73 | 0.81 | 42 | empty |
| 3 | 347 | 0.65 | 0.80 | 38 | empty |
| 4 | 63 | 0.28 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 955 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 2V28 · Apo structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q47XN7
- Elsewhere: RCSB PDB 2V28 · PDBe 2V28 · UniProt Q47XN7
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