MolNFT v1 · #51245 · protein
Crystal structure of the apo form of Y74F mutant E. COLI tryptophanase
2V1P · Trypthopanase: “Crystal structure of the apo form of Y74F mutant E. COLI tryptophanase”. X-ray diffraction, 2 ligands (MG, CL), 4 pockets (best druggability 0.62). MolNFT v1 #51245 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2V1P
- Type
- protein
- Length
- 467 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trypthopanase
- EC
- 4.1.99.1
- UniProt
- P0A853
- Ligands
- MG, CL
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trypthopanase (EC 4.1.99.1) | protein | 467 | 45% helix, 14% strand | P0A853 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.62 | 0.80 | 30 | empty |
| 2 | 364 | 0.58 | 0.75 | 41 | empty |
| 3 | 303 | 0.55 | 0.75 | 39 | empty |
| 4 | 183 | 0.51 | 0.78 | 28 | empty |
Modifications
Observed in the structure: 2 modified (artifact).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A853
- Elsewhere: RCSB PDB 2V1P · PDBe 2V1P · UniProt P0A853
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