MolNFT v1 · #51210 · protein

The structure of TAP42 ALPHA4 subunit

2V0P · Type 2A phosphatase-associated protein 42: “The structure of TAP42 ALPHA4 subunit”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.69). MolNFT v1 #51210 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2V0P
Type: protein
Length: 433 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Type 2A phosphatase-associated protein 42
UniProt: Q04372
Ligands: ZN
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Type 2A phosphatase-associated protein 42	protein	219	75% helix, 0% strand	Q04372
B	Type 2A phosphatase-associated protein 42	protein	214	79% helix, 0% strand	Q04372

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	617	0.69	0.78	61	empty
2	300	0.65	0.81	31	empty
3	175	0.43	0.74	30	empty
4	68	0.41	0.80	18	ZN
5	71	0.39	0.78	13	empty

Interfaces

1 interface between chains.

A–B · 1230 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

2V0P · The Structure of Tap42 Alpha4 Subunit · the same entry in another collection · chain A against A, TM-score 1.00
Q04372 · AlphaFold monomer V2.0 prediction for type 2A phosphatase-associated protein 42 (Q04372) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q04372
Elsewhere: RCSB PDB 2V0P · PDBe 2V0P · UniProt Q04372

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