MolNFT v1 · #51209 · protein
FCHO2 F-bar domain
2V0O · Fch domain only protein 2: “FCHO2 F-bar domain”. X-ray diffraction, 12 pockets (best druggability 0.75). MolNFT v1 #51209 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2V0O
- Type
- protein
- Length
- 816 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fch domain only protein 2
- UniProt
- Q96CF5
- Pockets
- 12 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 85% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fch domain only protein 2 | protein | 273 | 85% helix, 1% strand | Q96CF5 |
| B | Fch domain only protein 2 | protein | 271 | 84% helix, 1% strand | Q96CF5 |
| C | Fch domain only protein 2 | protein | 272 | 85% helix, 0% strand | Q96CF5 |
Ligands and binding sites
- ACT · Acetate ion · additive · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 77 | 0.75 | 0.98 | 22 | empty |
| 2 | 59 | 0.74 | 0.99 | 17 | ACT |
| 3 | 53 | 0.72 | 0.98 | 16 | ACT |
| 4 | 783 | 0.71 | 0.77 | 70 | empty |
| 5 | 565 | 0.66 | 0.77 | 46 | empty |
Interfaces
3 interfaces between chains.
- A–B · 4799 Ų buried · 40 hydrogen bonds · protein-protein
- A–C · 949 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 127 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 2V0O · FCHO2 F-BAR domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96CF5
- Elsewhere: RCSB PDB 2V0O · PDBe 2V0O · UniProt Q96CF5
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