MolNFT v1 · #5119 · protein

Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding domain of human fibronectin

1E8B: “Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding domain of human…”. Solution nmr, 1 ligand (NAG), 1 pocket (best druggability 0.41). MolNFT v1 #5119 on GenesisL1: 3D structure, binding sites…

PDB: 1E8B
Type: protein
Length: 160 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibronectin
UniProt: P02751
Ligands: NAG
Pockets: 1 · best druggability 0.41

Structure

solution nmr · 1 distinct chain · 7% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibronectin	protein	160	7% helix, 29% strand	P02751

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	106	0.41	0.77	19	empty

Modifications

Observed in the structure: 6 disulfide, 1 glycan (disulfide, N-glycosylation).

Compared structures

1E8B · Solution structure of 6F11F22F2, a compact three-module fragment of the gelatin-binding… · the same entry in another collection · chain A against A, TM-score 1.00
P02751 · AlphaFold monomer V2.0 prediction for fibronectin (P02751) · a predicted model of the same protein · chain A against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02751
Elsewhere: RCSB PDB 1E8B · PDBe 1E8B · UniProt P02751

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