MolNFT v1 · #51004 · protein

Crystal structure of C-phycocyanin from phormidium, lyngbya spp. (marine) and spirulina sp. (fresh water) shows two different ways of energy transfer between two hexamers.

2UUN: “Crystal structure of C-phycocyanin from phormidium, lyngbya spp. (marine) and spirulina sp. (fresh water)…”. X-ray diffraction, 2 ligands (CYC, BLA), 20 pockets (best druggability 0.84). MolNFT v1 #51004 on GenesisL1: 3D structure…

PDB: 2UUN
Type: protein
Length: 4,008 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-phycocyanin
Ligands: CYC, BLA
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 3 distinct chains · 76% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, I, K, M, O, Q, S, U, W	C-phycocyanin	protein	162	78% helix, 0% strand	—
B, F, H, J, L, N, P, R, T, V, X	C-phycocyanin	protein	172	76% helix, 0% strand	—
D	C-phycocyanin	protein	172	74% helix, 0% strand	—

Ligands and binding sites

CYC · Phycocyanobilin · ligand · 35 copies · chains A, D, B, C, F, K, E, I, G, J, H, L, M, P, N, S, O, R, W, Q, U, V, T, X
BLA · Biliverdine IX alpha · ligand · chains A, B, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.84	0.94	36	CYC
2	348	0.83	0.92	38	CYC
3	361	0.83	0.92	36	CYC
4	347	0.83	0.92	40	CYC
5	357	0.83	0.92	39	CYC

Interfaces

64 interfaces between chains.

U–V · 1587 Å² buried · 11 hydrogen bonds · protein-protein
Q–R · 1586 Å² buried · 12 hydrogen bonds · protein-protein
G–H · 1580 Å² buried · 11 hydrogen bonds · protein-protein
K–L · 1576 Å² buried · 14 hydrogen bonds · protein-protein
M–N · 1576 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 35 cofactor (phycocyanobilin attachment, biliverdin attachment).

Compared structures

2UUN · Crystal structure of C-phycocyanin from Phormidium, Lyngbya spp. (Marine) and Spirulina… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2UUN · PDBe 2UUN

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