MolNFT v1 · #51003 · protein

Crystal structure of C-phycocyanin from phormidium, lyngbya spp. (marine) and spirulina sp. (fresh water) shows two different ways of energy transfer between two hexamers.

2UUM · C-phycocyanin alpha chain: “Crystal structure of C-phycocyanin from phormidium, lyngbya spp. (marine) and spirulina sp. (fresh water)…”. X-ray diffraction, 2 ligands (BLA, CYC), 20 pockets (best druggability 0.84). MolNFT v1 #51003…

PDB: 2UUM
Type: protein
Length: 4,008 residues
Chains: 24
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-phycocyanin alpha chain; C-phycocyanin beta chain
UniProt: P72509, P72508
Ligands: BLA, CYC
Pockets: 20 · best druggability 0.84

Structure

x-ray diffraction · 3 distinct chains · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E, G, I, K, M, O, Q, S, U, W	C-phycocyanin alpha chain	protein	162	78% helix, 0% strand	P72509
B, D, F, H, J, L, N, P, R, T, V	C-phycocyanin beta chain	protein	172	76% helix, 0% strand	P72508
X	C-phycocyanin beta chain	protein	172	76% helix, 0% strand	P72508

Ligands and binding sites

BLA · Biliverdine IX alpha · ligand · 24 copies · chains B, A, K, D, C, I, F, E, G, H, L, J, N, M, W, P, O, U, Q, R, S, T, V, X
CYC · Phycocyanobilin · ligand · 12 copies · chains A, D, C, F, B, E, G, J, H, K, M, P, O, R, N, Q, S, V, U, X, T, W

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	333	0.84	0.93	39	CYC
2	365	0.84	0.92	37	CYC
3	341	0.83	0.92	38	CYC
4	355	0.83	0.92	39	CYC
5	342	0.83	0.92	37	CYC

Interfaces

67 interfaces between chains.

U–V · 1622 Å² buried · 14 hydrogen bonds · protein-protein
E–F · 1619 Å² buried · 14 hydrogen bonds · protein-protein
G–H · 1612 Å² buried · 12 hydrogen bonds · protein-protein
I–J · 1608 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 1608 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 cofactor (biliverdin attachment, phycocyanobilin attachment).

Compared structures

2UUM · Crystal structure of C-phycocyanin from Phormidium, Lyngbya spp. (Marine) and Spirulina… · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P72509
Every structure of UniProt P72508
Elsewhere: RCSB PDB 2UUM · PDBe 2UUM · UniProt P72509 · UniProt P72508

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