MolNFT v1 · #5091 · protein

Human serum albumin complexed with hexadecanoic acid (palmitic acid)

1E7H: “Human serum albumin complexed with hexadecanoic acid (palmitic acid)”. X-ray diffraction, 1 ligand (PLM), 7 pockets (best druggability 0.90). MolNFT v1 #5091 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1E7H
Type: protein
Length: 581 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serum albumin
UniProt: P02768
Ligands: PLM
Pockets: 7 · best druggability 0.90

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serum albumin	protein	581	74% helix, 0% strand	P02768

Ligands and binding sites

PLM · Palmitic acid · ligand · 7 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1022	0.90	0.91	99	PLM
2	326	0.80	0.90	39	PLM
3	408	0.75	0.84	34	PLM
4	253	0.69	0.84	35	PLM
5	83	0.60	0.88	15	PLM

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

1E7H · Human serum albumin complexed with hexadecanoic acid (palmitic acid) · the same entry in another collection · chain A against A, TM-score 1.00
P02768 · AlphaFold monomer V2.0 prediction for albumin (P02768) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02768
Elsewhere: RCSB PDB 1E7H · PDBe 1E7H · UniProt P02768

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