MolNFT v1 · #5090 · protein

Human serum albumin complexed with tetradecanoic acid (myristic acid)

1E7G: “Human serum albumin complexed with tetradecanoic acid (myristic acid)”. X-ray diffraction, 1 ligand (MYR), 9 pockets (best druggability 0.87). MolNFT v1 #5090 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1E7G
Type: protein
Length: 582 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serum albumin
UniProt: P02768
Ligands: MYR
Pockets: 9 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serum albumin	protein	582	73% helix, 0% strand	P02768

Ligands and binding sites

MYR · Myristic acid · ligand · 8 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	601	0.87	0.92	66	MYR
2	299	0.83	0.93	33	MYR
3	330	0.81	0.91	43	MYR
4	352	0.73	0.84	26	MYR
5	235	0.69	0.85	35	MYR

Modifications

Observed in the structure: 17 disulfide (disulfide).

Compared structures

1E7G · Human serum albumin complexed with tetradecanoic acid (myristic acid) · the same entry in another collection · chain A against A, TM-score 1.00
P02768 · AlphaFold monomer V2.0 prediction for albumin (P02768) · a predicted model of the same protein · chain A against A, TM-score 0.84

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02768
Elsewhere: RCSB PDB 1E7G · PDBe 1E7G · UniProt P02768

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