MolNFT v1 · #50808 · protein

Chemical shift assignments for mip and MDM2 in bound state

2RUH · E3 ubiquitin-protein ligase MDM2: “Chemical shift assignments for mip and MDM2 in bound state”. Solution nmr, 1 pocket (best druggability 0.48). MolNFT v1 #50808 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RUH
Type: protein
Length: 131 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase MDM2
EC: 6.3.2.-
UniProt: Q00987
Pockets: 1 · best druggability 0.48

Structure

solution nmr · 1 distinct chain · 40% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase MDM2 (EC 6.3.2.-)	protein	131	40% helix, 8% strand	Q00987

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	195	0.48	0.75	20	empty

Compared structures

2RUH · Chemical Shift Assignments for MIP and MDM2 in bound state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00987
Elsewhere: RCSB PDB 2RUH · PDBe 2RUH · UniProt Q00987

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