MolNFT v1 · #50764 · protein

Structural insights into the recruitment of smrt by the co-repressor sharp under phosphorylative regulation

2RT5 · MSX2-interacting protein: “Structural insights into the recruitment of smrt by the co-repressor sharp under phosphorylative regulation”. Solution nmr. MolNFT v1 #50764 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RT5
Type: protein
Length: 177 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MSX2-interacting protein; Peptide from silencing mediator of retinoic acid and thyroid…
UniProt: Q96T58, Q9Y618

Structure

solution nmr · 2 distinct chains · 34% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MSX2-interacting protein	protein	169	36% helix, 31% strand	Q96T58
B	Peptide from silencing mediator of retinoic acid and thyroid hormone receptor	protein	8	0% helix, 0% strand	Q9Y618

Interfaces

1 interface between chains.

A–B · 663 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (phosphorylation).

Compared structures

2RT5 · Structural insights into the recruitment of SMRT by the co-repressor SHARP under… · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y618 · AlphaFold monomer V2.0 prediction for nuclear receptor corepressor 2 (Q9Y618) · a predicted model of the same protein · chain B against A, TM-score 0.35

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96T58
Every structure of UniProt Q9Y618
Elsewhere: RCSB PDB 2RT5 · PDBe 2RT5 · UniProt Q96T58 · UniProt Q9Y618

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