MolNFT v1 · #50750 · protein
Refinement of gamma delta resolvase reveals a strikingly flexible molecule
2RSL · Gamma delta-resolvase: “Refinement of gamma delta resolvase reveals a strikingly flexible molecule”. X-ray diffraction, 1 ligand (SO4), 3 pockets (best druggability 0.67). MolNFT v1 #50750 on GenesisL1: 3D structure, binding sites…
- PDB
- 2RSL
- Type
- protein
- Length
- 354 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma delta-resolvase
- UniProt
- P03012
- Ligands
- SO4
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 50% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma delta-resolvase | protein | 115 | 51% helix, 19% strand | P03012 |
| B | Gamma delta-resolvase | protein | 120 | 49% helix, 18% strand | P03012 |
| C | Gamma delta-resolvase | protein | 119 | 49% helix, 18% strand | P03012 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.67 | 0.82 | 37 | empty |
| 2 | 67 | 0.35 | 0.77 | 15 | empty |
| 3 | 57 | 0.26 | 0.73 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–B · 727 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 590 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 2RSL · Refinement of gamma delta resolvase reveals a strikingly flexible molecule · the same entry in another collection · chain A against A, TM-score 1.00
- P03012 · AlphaFold monomer V2.0 prediction for transposon gamma-delta resolvase (P03012) · a predicted model of the same protein · chain B against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03012
- Elsewhere: RCSB PDB 2RSL · PDBe 2RSL · UniProt P03012
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