MolNFT v1 · #50674 · protein

Solution structure of mouse lipocalin-type prostaglandin D synthase possessing the intrinsic disulfide bond

2RQ0 · Prostaglandin-H2 D-isomerase: “Solution structure of mouse lipocalin-type prostaglandin D synthase possessing the intrinsic disulfide bond”. Solution nmr, 3 pockets (best druggability 0.78). MolNFT v1 #50674 on GenesisL1: 3D…

PDB: 2RQ0
Type: protein
Length: 167 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prostaglandin-H2 D-isomerase
EC: 5.3.99.2
UniProt: O09114
Pockets: 3 · best druggability 0.78

Structure

solution nmr · 1 distinct chain · 16% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Prostaglandin-H2 D-isomerase (EC 5.3.99.2)	protein	167	16% helix, 40% strand	O09114

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	682	0.78	0.82	61	empty
2	59	0.46	0.84	18	empty
3	126	0.43	0.76	27	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

2RQ0 · Solution Structure of Mouse Lipocalin-type Prostaglandin D Synthase Possessing the… · the same entry in another collection · chain A against A, TM-score 1.00
O09114 · AlphaFold monomer V2.0 prediction for prostaglandin-H2 D-isomerase (O09114) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O09114
Elsewhere: RCSB PDB 2RQ0 · PDBe 2RQ0 · UniProt O09114

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