MolNFT v1 · #50653 · protein
Solution structure of the oligomerization domain in DMP53
2RP4 · Transcription factor P53: “Solution structure of the oligomerization domain in DMP53”. Solution nmr, 2 pockets (best druggability 0.50). MolNFT v1 #50653 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2RP4
- Type
- protein
- Length
- 284 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor P53
- UniProt
- Q9N6D8
- Pockets
- 2 · best druggability 0.50
Structure
solution nmr · 1 distinct chain · 56% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transcription factor P53 | protein | 71 | 56% helix, 15% strand | Q9N6D8 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.50 | 0.76 | 33 | empty |
| 2 | 79 | 0.34 | 0.75 | 19 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2006 Ų buried · 27 hydrogen bonds · protein-protein
- A–B · 1993 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 545 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 537 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 64 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2RP4 · Solution Structure of the oligomerization domain in Dmp53 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9N6D8
- Elsewhere: RCSB PDB 2RP4 · PDBe 2RP4 · UniProt Q9N6D8
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