MolNFT v1 · #50634 · protein

The DNA binding domain of RTBP1

2ROH · Telomere binding protein-1: “The DNA binding domain of RTBP1”. Solution nmr, 2 pockets (best druggability 0.55). MolNFT v1 #50634 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2ROH
Type: protein
Length: 122 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Telomere binding protein-1
UniProt: Q9LL45
Pockets: 2 · best druggability 0.55

Structure

solution nmr · 1 distinct chain · 44% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Telomere binding protein-1	protein	122	44% helix, 0% strand	Q9LL45

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	200	0.55	0.78	29	empty
2	135	0.52	0.80	17	empty

Compared structures

2ROH · The DNA binding domain of RTBP1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9LL45 · AlphaFold monomer V2.0 prediction for telomere-binding protein 1 (Q9LL45) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9LL45
Elsewhere: RCSB PDB 2ROH · PDBe 2ROH · UniProt Q9LL45

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