MolNFT v1 · #50630 · protein
Solution structure of mcl-1 complexed with puma
2ROC · Induced myeloid leukemia cell differentiation protein mcl-1…: “Solution structure of mcl-1 complexed with puma”. Solution nmr. MolNFT v1 #50630 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2ROC
- Type
- protein
- Length
- 189 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Induced myeloid leukemia cell differentiation protein mcl-1 homolog; BCL-2-binding…
- UniProt
- P97287, Q99ML1
Structure
solution nmr · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Induced myeloid leukemia cell differentiation protein mcl-1 homolog | protein | 162 | 76% helix, 0% strand | P97287 |
| B | BCL-2-binding component 3 | protein | 27 | 81% helix, 0% strand | Q99ML1 |
Interfaces
1 interface between chains.
- A–B · 1014 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 2ROC · Solution structure of Mcl-1 Complexed with Puma · the same entry in another collection · chain A against A, TM-score 1.00
- P97287 · AlphaFold monomer V2.0 prediction for induced myeloid leukemia cell differentiation… · a predicted model of the same protein · chain A against A, TM-score 0.88
- Q99ML1 · AlphaFold monomer V2.0 prediction for BCL-2-binding component 3 (Q99ML1) · a predicted model of the same protein · chain B against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P97287
- Every structure of UniProt Q99ML1
- Elsewhere: RCSB PDB 2ROC · PDBe 2ROC · UniProt P97287 · UniProt Q99ML1
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