MolNFT v1 · #50609 · protein
Structure of the het-S(218-289) prion in its amyloid form obtained by solid-state NMR
2RNM · Small S protein: “Structure of the het-S(218-289) prion in its amyloid form obtained by solid-state NMR”. Solution nmr, 8 pockets (best druggability 0.70). MolNFT v1 #50609 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 2RNM
- Type
- protein
- Length
- 395 residues
- Chains
- 5
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small S protein
- UniProt
- Q03689
- Pockets
- 8 · best druggability 0.70
Structure
solution nmr · 1 distinct chain · 0% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Small S protein | protein | 79 | 0% helix, 35% strand | Q03689 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.70 | 0.90 | 31 | empty |
| 2 | 544 | 0.69 | 0.79 | 57 | empty |
| 3 | 277 | 0.64 | 0.81 | 58 | empty |
| 4 | 144 | 0.59 | 0.84 | 36 | empty |
| 5 | 65 | 0.44 | 0.83 | 17 | empty |
Interfaces
9 interfaces between chains.
- B–C · 2244 Ų buried · 40 hydrogen bonds · protein-protein
- C–D · 2148 Ų buried · 44 hydrogen bonds · protein-protein
- A–B · 1826 Ų buried · 40 hydrogen bonds · protein-protein
- D–E · 1790 Ų buried · 42 hydrogen bonds · protein-protein
- B–D · 177 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2RNM · Structure of The HET-s(218-289) prion in its amyloid form obtained by solid-state NMR · the same entry in another collection · chain A against A, TM-score 1.00
- Q03689 · AlphaFold monomer V2.0 prediction for heterokaryon incompatibility protein S (Q03689) · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q03689
- Elsewhere: RCSB PDB 2RNM · PDBe 2RNM · UniProt Q03689
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.