MolNFT v1 · #50552 · protein

Split pH domain of PI3-kinase enhancer

2RLO · Centaurin-gamma 1: “Split pH domain of PI3-kinase enhancer”. Solution nmr, 1 pocket (best druggability 0.42). MolNFT v1 #50552 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RLO
Type: protein
Length: 128 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Centaurin-gamma 1
UniProt: Q99490
Pockets: 1 · best druggability 0.42

Structure

solution nmr · 1 distinct chain · 20% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Centaurin-gamma 1	protein	128	20% helix, 32% strand	Q99490

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.42	0.76	19	empty

Compared structures

2RLO · Split PH domain of PI3-kinase enhancer · the same entry in another collection · chain A against A, TM-score 1.00
Q99490 · AlphaFold monomer V2.0 prediction for arf-gap with GTPase, ank repeat and pH… · a predicted model of the same protein · chain A against A, TM-score 0.74

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99490
Elsewhere: RCSB PDB 2RLO · PDBe 2RLO · UniProt Q99490

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.