MolNFT v1 · #5046 · protein

Zn-azurin from pseudomonas aeruginosa

1E67: “Zn-azurin from pseudomonas aeruginosa”. X-ray diffraction, 2 ligands (ZN, NO3), 5 pockets (best druggability 0.73). MolNFT v1 #5046 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1E67
Type: protein
Length: 512 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Azurin
UniProt: P00282
Ligands: ZN, NO3
Pockets: 5 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Azurin	protein	128	16% helix, 34% strand	P00282

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
NO3 · Nitrate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	240	0.73	0.88	30	empty
2	288	0.67	0.82	35	empty
3	58	0.65	0.94	19	empty
4	261	0.63	0.81	49	empty
5	266	0.62	0.80	42	empty

Interfaces

6 interfaces between chains.

A–C · 529 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 503 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 419 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 412 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 398 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1E67 · Zn-Azurin from Pseudomonas aeruginosa · the same entry in another collection · chain D against D, TM-score 1.00
P00282 · AlphaFold monomer V2.0 prediction for azurin (P00282) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00282
Elsewhere: RCSB PDB 1E67 · PDBe 1E67 · UniProt P00282

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