MolNFT v1 · #50402 · protein
Crystal structures of the luciferase and green fluorescent protein from renilla reniformis
2RH7: “Crystal structures of the luciferase and green fluorescent protein from renilla reniformis”. X-ray diffraction, 1 ligand (CRO), 8 pockets (best druggability 0.75). MolNFT v1 #50402 on GenesisL1: 3D structure, binding sites and…
- PDB
- 2RH7
- Type
- protein
- Length
- 845 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green fluorescent protein
- UniProt
- Q963I9
- Ligands
- CRO
- Pockets
- 8 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Green fluorescent protein | protein | 211 | 3% helix, 57% strand | Q963I9 |
| B | Green fluorescent protein | protein | 212 | 5% helix, 58% strand | Q963I9 |
Ligands and binding sites
- CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1108 | 0.75 | 0.78 | 102 | empty |
| 2 | 68 | 0.74 | 0.99 | 22 | CRO |
| 3 | 64 | 0.72 | 0.98 | 23 | CRO |
| 4 | 86 | 0.37 | 0.76 | 16 | empty |
| 5 | 96 | 0.37 | 0.75 | 19 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1339 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1327 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 168 Ų buried · 3 hydrogen bonds · protein-protein
- B–D · 162 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 83 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2RH7 · Crystal Structures of the Luciferase and Green Fluorescent Protein from Renilla Reniformis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q963I9
- Elsewhere: RCSB PDB 2RH7 · PDBe 2RH7 · UniProt Q963I9
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