MolNFT v1 · #50348 · protein

Crystral structure of the nucleoporin NIC96

2RFO: “Crystral structure of the nucleoporin NIC96”. X-ray diffraction, 15 pockets (best druggability 0.75). MolNFT v1 #50348 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2RFO
Type: protein
Length: 1,221 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin NIC96
UniProt: P34077
Pockets: 15 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin NIC96	protein	612	58% helix, 1% strand	P34077
B	Nucleoporin NIC96	protein	609	56% helix, 3% strand	P34077

Pockets

15 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	761	0.75	0.80	63	empty
2	160	0.61	0.84	22	empty
3	315	0.59	0.78	34	empty
4	152	0.45	0.76	25	empty
5	62	0.42	0.82	14	empty

Interfaces

1 interface between chains.

A–B · 1254 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

2RFO · Crystral Structure of the nucleoporin Nic96 · the same entry in another collection · chain A against A, TM-score 1.00
P34077 · AlphaFold monomer V2.0 prediction for nucleoporin NIC96 (P34077) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P34077
Elsewhere: RCSB PDB 2RFO · PDBe 2RFO · UniProt P34077

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