MolNFT v1 · #5032 · protein
Prolyl oligopeptidase from porcine brain, mutant
1E5T · Prolyl endopeptidase: “Prolyl oligopeptidase from porcine brain, mutant”. X-ray diffraction, 8 pockets (best druggability 0.75). MolNFT v1 #5032 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1E5T
- Type
- protein
- Length
- 710 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prolyl endopeptidase
- EC
- 3.4.21.26
- UniProt
- P23687
- Pockets
- 8 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prolyl endopeptidase (EC 3.4.21.26) | protein | 710 | 23% helix, 34% strand | P23687 |
Ligands and binding sites
- GOL · Glycerol · additive · 9 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 822 | 0.75 | 0.79 | 80 | empty |
| 2 | 457 | 0.66 | 0.78 | 36 | GOL |
| 3 | 277 | 0.56 | 0.77 | 35 | GOL |
| 4 | 98 | 0.48 | 0.81 | 23 | empty |
| 5 | 98 | 0.41 | 0.77 | 18 | empty |
Modifications
Observed in the structure: 1 covalent, 1 disulfide (additive adduct, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23687
- Elsewhere: RCSB PDB 1E5T · PDBe 1E5T · UniProt P23687
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